Services

The increasing recognition of the critical role that the Ubiquitin Proteasome Pathway (UPP) plays in cellular signaling coupled with the validation of the therapeutic potential of targets in this pathway is accelerating interest in the drug discovery potential of this field amongst both academic and pharmaceutical researchers.

Ubiquigent was founded upon the extensive experience and know-how of its collaborators and employees in providing custom services to researchers in the field of kinase drug discovery. Given the considerable therapeutic target opportunity becoming increasingly apparent within the UPP, we seek to apply our proven expertise to offer specialized services that enable you to accelerate drug discovery in this new and exciting field.

NEW! DUBprofiler™ Compound Screening Service

Determine the selectivity and potency of your DUB inhibitors by single concentration profiling and IC₅₀ analysis.

WHAT YOU DO:

• Send us your compound(s).
• Request single concentration profiling and/or IC₅₀ analysis (electronic submission).

WHAT WE DO:

• Determine the selectivity and specificity of your deubiquitinase (DUB) inhibitor lead compound(s).
• Electronically report fully quality controlled data to you (single concentration % activities or IC₅₀s).

SERVICE HIGHLIGHTS:

• 21 DUBs on the panel and expanding.
• Any scale and combination of screening; compound(s) vs. DUB(s).
• 2 week service cycle.

LEARN MORE. For further details, click HERE. Email us to learn more about how the service operates and to discuss your specific requirements. mailto:services@ubiquigent.com.

Custom assay development

As pathways and functions are unraveled, new and attractive UPP drug discovery targets are coming to light with relevance across many key therapeutic areas. With access to a wide range of reagents and through our knowledge and expertise of working with these pathways - both internally and through our collaborations with Sir Philip Cohen and other leaders in the field - Ubiquigent’s Custom Assay Development team will support pharmaceutical and biotech companies in translating these discoveries into lead programs.

We will work closely and collaboratively with you throughout our partnership. Our approach is highly flexible; from providing high quality activity validated reagents to developing the required screening and deconvolution assays and supplying the reagents to enable you to conduct your HTS campaign in-house.

If you are interested in determining the effect of test compounds in (UPP) target activity profiling assays or any of our custom drug discovery services, please email us at services@ubiquigent.com.