Enabling Protein Degradation Drug Discovery

DUBtoolkit

A proprietary tool to support the development of regulators of the ubiquitin-like-protein pathways:

An ever increasing  amount of classified and unclassified data are entering the public domain and one of the challenges is to extract information that has the potential to support and inform compound design from these diverse data sources. A further key challenge is how to integrate and interpret these different sources of information in a way that provides insight into the design of novel probes and drug leads.

Our solution is the DUBtoolkit™, a continuously evolving knowledge graph and associated set of data mining tools which captures relationships between enzymes in the ubiquitin and ubiquitin-like protein pathways using structural, genomic, biochemical and biological data in a way that has been optimised for exploitation by our medicinal and computational chemists in the design of novel probes and drug leads.

The DUBtoolkit™ forms an intrinsic part of our Collaborative Drug Discovery programmes.  If you would like to learn more about how we can use our DUBtoolkit™ as part of a Collaborative Drug Discovery partnership please contact us at partnerships@ubiquigent.com.