Enabling Protein Degradation Drug Discovery

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Cul2/Rbx1 [untagged]

Posted on March 5th, 2014 in
The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome-dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes (E1s),… Read more

Cul1/Rbx1 [untagged]

Posted on July 19th, 2013 in
The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes… Read more

Cul1/Rbx1/Skp1 [untagged]

Posted on July 19th, 2013 in
The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes… Read more

Cul3/Rbx1 [untagged]

Posted on July 19th, 2013 in
The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes… Read more

Cul5/Rnf7 [untagged]

Posted on July 19th, 2013 in
The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes… Read more