Enabling Protein Degradation Drug Discovery

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Parkin [untagged]

Posted on May 6th, 2014 in

MAPK3 [untagged]

Posted on March 5th, 2014 in
Please see Certificate of Analysis for Background Information

Cul2/Rbx1 [untagged]

Posted on March 5th, 2014 in
The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome-dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes (E1s),… Read more

MuRF1 [untagged]

Posted on March 5th, 2014 in
The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome-dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes (E1s),… Read more

USP8 [untagged]

Posted on March 4th, 2014 in

NEDD8 [untagged]

Posted on July 20th, 2013 in
The enzymes of the NEDDylation pathway play a pivotal role in the activation of the largest class of ubiquitin E3 ligases called Cullin RING Ligases (CRLs). Akin to ubiquitylation three classes of enzymes are involved in the process of mammalian… Read more

Cul1/Rbx1/Skp1 [untagged]

Posted on July 19th, 2013 in
The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes… Read more

Cul3/Rbx1 [untagged]

Posted on July 19th, 2013 in
The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes… Read more

Cul5/Rnf7 [untagged]

Posted on July 19th, 2013 in
The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes… Read more

S5a [untagged]

Posted on July 19th, 2013 in
The ubiquitin–proteasome system (UPS) targets selected proteins for degradation by the 26S proteasome. The initial steps in this pathway generate proteins that are covalently tagged with a polyubiquitin chain that is then recognized by ubiquitin receptors of the 26S proteasome.… Read more