Linking Ubiquitin Research to Drug Discovery

Therapeutic Areas and the Ubiquitin System

As the pathways and networks of cell signalling are revealed, the variety and complexity of protein modifications that regulate cellular functions continues to grow. The critical role that the ubiquitin cascade plays in cellular signalling and protein homeostasis, coupled with increasing validation of the therapeutic potential of targets in this pathway, is accelerating interest in ubiquitin system-targeted drug discovery.

In this section we have sought to begin assembling proteins of the ubiquitin system into four groups according to their relevance to key therapeutic areas. This is not intended to be an exhaustive list but one that highlights some of the most recent work in a variety of therapeutic areas, and one that adds weight to the notion of various ubiquitin system proteins as potentially attractive new targets for medicinal chemistry and drug therapy.